翻訳と辞書 Words near each other ・ Protein G ・ Protein geranylgeranyltransferase type I ・ Protein geranylgeranyltransferase type II ・ Protein histidine kinase ・ Protein I-sites ・ Protein IB5 ・ Protein Information Resource ・ Protein inhibitor of activated STAT ・ Protein inhibitor of activated STAT2 ・ Protein isoform ・ Protein K ・ Protein K (gene expression) ・ Protein K (porin) ・ Protein kinase ・ Protein kinase A ・ Protein kinase B ・ Protein kinase C ・ Protein kinase C zeta type ・ Protein kinase D1 ・ Protein kinase domain ・ Protein kinase inhibitor ・ Protein kinase N1 ・ Protein kinase R ・ Protein kinase, AMP-activated, alpha 1 ・ Protein L ・ Protein ligand ・ Protein Local Optimization Program ・ Protein losing enteropathy ・ Protein M ・ Protein mass spectrometry Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Protein kinase B ： ウィキペディア英語版 Protein kinase B Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. ==Family members== Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Mouse model with complete deletion of Akt1 manifests growth retardation and increased spontaneous apoptosis in tissues such as testes and thymus. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogene in the transforming retrovirus, AKT8. Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport. In a mouse which is null for Akt1 but normal for Akt2, glucose homeostasis is unperturbed, but the animals are smaller, consistent with a role for Akt1 in growth. In contrast, mice which do not have Akt2, but have normal Akt1, have mild growth deficiency and display a diabetic phenotype (insulin resistance), again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. Akt isoforms are overexpressed in a variety of human tumors, and, at the genomic level, are amplified in gastric adenocarcinomas (Akt1), ovarian (Akt2), pancreatic (Akt2) and breast (Akt2) cancer. The role of Akt3 is less clear, though it appears to be predominantly expressed in the brain. It has been reported that mice lacking Akt3 have small brains. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Protein kinase B」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.